Maternal obesity drives functional alterations in uterine NK cells
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چکیده
منابع مشابه
Maternal obesity drives functional alterations in uterine NK cells.
Over one-fifth of North American women of childbearing age are obese, putting these women at risk for a variety of detrimental chronic diseases. In addition, obesity increases the risk for developing major complications during pregnancy. The mechanisms by which obesity contributes to pregnancy complications and loss remain unknown. Increasing evidence indicates that obesity results in major cha...
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In pregnancy, uterine natural killer cells (uNK) play essential roles in coordinating uterine angiogenesis, blood vessel remodeling, and promoting maternal tolerance to fetal tissue. Deviances from a normal uterine microenvironment are thought to modify uNK function(s) by limiting their ability to establish a healthy pregnancy. While maternal obesity has become a major health concern due to ass...
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Pregnancy presents an immunological conundrum because two genetically different individuals coexist. The maternal lymphocytes at the uterine maternal-fetal interface that can recognize mismatched placental cells are T cells and abundant distinctive uterine NK (uNK) cells. Multiple mechanisms exist that avoid damaging T cell responses to the fetus, whereas activation of uNK cells is probably phy...
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The presence of immune cells in the placental bed is important for both mother and child. Although various immune cells can be found in the placental bed, such as regulatory T cells and dendritic cells, uterine NK cells and macrophages are the most prominent immune cells in the placental bed in early pregnancy. uNK cell and macrophage numbers in the placental bed decrease in the third trimester...
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The decline to low or undetectable SBA and IgG antibody levels within a year after completion of primary MACC immunization (table 1) indicates that long-term protection can be achieved only if children are primed for memory responses and can rapidly produce specific IgG of relatively high avidity on encounter with the appropriate antigen. Further studies to investigate the kinetics of the serum...
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ژورنال
عنوان ژورنال: JCI Insight
سال: 2016
ISSN: 2379-3708
DOI: 10.1172/jci.insight.85560